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The gastro-resistant properties of the sucrosome shields the vitamin from premature release, degradation and minimizing interactions with food (27), as it passes through the stomach, ensuring that the B12 reaches the intestinal mucosa intact

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Once a more complete picture of the molecular characteristics of the different populations of enteric glial cells emerges, functionally identified, molecularly characterized subsets of enteric glia are likely to be found to play a variety of key signaling functions in the GI tract, including the promotion of intestinal homeostasis and barrier function, as we discuss below