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doi: 10.1186/s12964-018-0268-4 155 ZegeyeMMMaticLLengquistMHayderiAGrenegrdMHedinUet al

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A skin biopsy, measurement of metabolites (such as serum methyl malonic acid and homocysteine), and a Schilling test would have thrown more light on the diagnosis

GOPO works by stopping excess white blood cells from gathering around inflamed tissue, thereby helping to break the cycle of inflammation and protect cartilage
