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Conclusion Whilst severe B12 deficiency has a clear clinical picture with characteristic haematological and/or neurological features, establishing mild or borderline deficiency can be problematic as serum levels are maintained at the expense of tissue concentrations, and therefore serum levels of B12 may be in the low normal or borderline range despite a deficiency

To address this pathological characteristic, hydrogels have emerged as ideal intervention carriers due to their superior controlled-release capabilities

Case definition Each person attending the medical centre and presenting cutaneous infection in an area previously treated with mesotherapy, during the period between 1st October 2008 and 26 February 2009, was considered for the study

639,640 The high affinity of squalamine for these membranes effectively displaces -synuclein, reducing the local concentration of the protein at the membrane interface and preventing it from adopting aggregation-prone conformations