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3.2.2 Parkin ( PARK2 ) Parkin, encoded by PARK2 , is an E3 ubiquitin-protein ligase critical in protein homeostasis via monoubiquitylation, multiple monoubiquitylation, and K48-/K63-linked polyubiquitylation

We tested this hypothesis by measuring sleep state timing and EEG parameters in animals subjected to NAC administration

Dijke IE, Hoeppli RE, Ellis T, Pearcey J, Huang Q, McMurchy AN, et al

Cremades N et al

Coupling reactions were performed with Fmoc-Xaa-OH in DMF (400 l, 0.4 M, 4.0 equiv.), HBTU in DMF (420 l, 0.38 M, 4.0 equiv.) and i Pr 2 NEt in NMP (200 l, 1.6 M, 8.0 equiv.) for 40 min, followed by washing with DMF (3 45 s)