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Conversely, ferroptosis related lipid metabolism in tumor microenvironment (TME) affects CD8 + T cell function: arachidonic acid (AA), an 6 polyunsaturated fatty acid transported by CD36, induces ferroptosis in CD8 + T cells, reducing the secretion of IFN, TNF, and perforin (a key effector molecule for tumor cell apoptosis) and ultimately impairing their anti-tumor activity [85, 86]

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Clin Cancer Res 9(16 Pt 1):58535859 Nakayama K, Kanzaki A, Ogawa K, Miyazaki K, Neamati N, Takebayashi Y (2002) Copper-transporting P-type adenosine triphosphatase (ATP7B) as a cisplatin based chemoresistance marker in ovarian carcinoma: comparative analysis with expression of MDR1, MRP1, MRP2