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[DOI] [PubMed] [Google Scholar] Kowaltowski AJ, Fiskum G

Andersson, Emmanuel Shapira, Biochemical and clinical response to hydroxocobalamin versus cyanocobalamin treatment in patients with methylmalonic acidemia and homocystinuria (cblC), The Journal of Pediatrics, Volume 132, Issue 1, January 1998, Pages 121-124, ISSN 0022-3476, Okuda K, Yashima K, Kitazaki T, Takara I

Directing the stream straight at the lyophilized cake can damage the peptide through mechanical force

Because of this, hydroquinone, often in combination with Vitamin A and steroids, remains the gold standard for treating melasma

Doubt that has much to do with it
