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Effects of Heterocyclic N-alkyl Chain Length on Cancer Cell Uptake of Near Infrared Heptamethine Cyanine Dyes

Introduction: A Breakthrough in Metabolic Modulation

This deficiency can lead to megaloblastic anemia, where the body produces large, abnormal red blood cells that cannot function effectively, resulting in symptoms such as fatigue, weakness, and neurological issues

Additionally, endoxifen, but not 4HT, is able to block estrogen-induced changes in gene expression at clinically relevant levels

We posit that combining quantitative MS and CETSA in gold-based thermal proteome profiling will be a powerful analytical strategy to decipher the MoA of Au drug candidates or chemical probes