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Specifically, the GPX4 inhibitors RSL3 and ML210 were identified to selectively kill melanoma persisters derived with BRAFi and MEKi treatments 12

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In addition to depleting intrahepatic GSH, APAP seems to decrease the activity of anti-oxidant enzymes (SOD, CAT, GPx), as well as of enzymes involved in glutathione redox cycling (glutathione reductase, GR), utilization (glutathione S-transferase, GST) and synthesis (gamma-glutamylcysteine synthetase) (237)

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This is why early diagnosis and treatment matter

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It is worth mentioning that the Au 2943 (SG) 2737 NCs with GSH ligands on the NC surface featured with a different biodistribution from that of the Cy5-labeled Au 25 (SG) 18 46

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