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Specifically, the GPX4 inhibitors RSL3 and ML210 were identified to selectively kill melanoma persisters derived with BRAFi and MEKi treatments 12

In addition to depleting intrahepatic GSH, APAP seems to decrease the activity of anti-oxidant enzymes (SOD, CAT, GPx), as well as of enzymes involved in glutathione redox cycling (glutathione reductase, GR), utilization (glutathione S-transferase, GST) and synthesis (gamma-glutamylcysteine synthetase) (237)

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It is worth mentioning that the Au 2943 (SG) 2737 NCs with GSH ligands on the NC surface featured with a different biodistribution from that of the Cy5-labeled Au 25 (SG) 18 46
