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Recently, a new mechanism has been proposed, known as the sequential proton loss electron transfer (SPLET) mechanism

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Access this article Similar content being viewed by others Abbreviations RBC: Red blood cells ROS: Reactive oxygen species CCl4: Carbon tetrachloride PCM: Paracetamol HCC: Hepatocellular carcinoma NSAIDS: Non-steroidal anti-inflammatory drugs DEN: Diethylnitrosamine NAPQI: N -Acetyl-p-benzo-quinoneimine TB: Tuberculosis INH: Isoniazid RIF: Rifampicin BAC: Blood alcohol concentration ADH: Alcohol dehydrogenase ALDH: Acetaldehyde dehydrogenase NAFLD: Non-alcoholic fatty liver disease TAG: Triacylglycerols IR: Insulin resistance BDL: Bile duct ligation KO: Knockout mouse NADH: Nicotinamide adenine dinucleotide SGOT: Serum glutamic oxaloacetate transaminase SGPT: Serum glutamic pyruvic transaminase ALP: Alkaline phosphatase ALT: Alanine aminotransferase AST: Aspartate aminotransferases TB: Total bilirubin AFB: Aflatoxin B1 CYP: Cytochrome P450 PVL: Portal vein ligation HSCs: Hepatic stellate cells GGT: Gamma glutamyltransferase LDH: Lactate dehydrogenase GSH: Glutathione References Bigoniya P, Singh CS, Shukla A