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For dogs battling cancer, immune support is essential

10.1177/1177271917691035 [DOI] [PMC free article] [PubMed] [Google Scholar] 105.Khemakhem AM, Frye RE, El-Ansary A, Al-Ayadhi L, Bacha AB

10.1177/153537020623100918 [DOI] [PubMed] [Google Scholar] 155

Brain repair and BBB permeability are strongly linked to lesion volume and stroke severity, as well as to neuroinflammation characterized by activated microglia and inflammatory cytokines[52]

However, these mainstream therapies face critical limitations including the rapid emergence of drug resistance, FKS1/FKS2 gene mutations reducing -1,3-glucan synthase affinity, Targeted enzyme (Erg11p) modification, overexpression of efflux pumps (CDR1, MDR1), and upregulation of the ergosterol pathway mediate azole resistance (Pristov and Ghannoum, 2019)
