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Together, our observations that a small molecule NNMT inhibitor can increase NAD + and SAM concentrations in differentiated adipocytes and reduce adiposity in DIO mice, suggest that treatment with an NNMT inhibitor effectively reverses obesity via modulation of the NAD + salvage and SAM-mediated (e.g., polyamine flux) pathways to regulate energy expenditure in the adipose tissue

United States Research has primarily focused on its mechanisms of action, which suggest an enhancement in the processes of angiogenesis (the development of new blood vessels), tissue granulation, and collagen reformation

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Human data is limited primarily to topical dermatological applications