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Besides prescribing drugs that can slow progression, doctors can offer a range of medications to treat ALS-related symptoms, including modafinil (Provigil) for fatigue, mexiletine for muscle cramps, gabapentin (Horizant) for chronic pain, antidepressants for depression, and dexmedetomidine (Precedex) for sleep disorders
Owing to their structural diversity and multi-target activities, they regulate interconnected pathways involved in inflammation, oxidative stress, and immune responses (Zhao et al., 2025
Cellular glutathione concentrations typically range from 110 millimoles per liter, with concentration highest in liver, red blood cells, and immune cells
TMPRSS2 expression dictates the entry route used by SARS-CoV-2 to infect host cells
MET has been shown to remain active post-endocytosis and furthermore to require endocytosis to sustain its activation and/or downstream signalling [3,4,5]
