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Chronic enrichment of hepatic endoplasmic reticulummitochondria contact leads to mitochondrial dysfunction in obesity

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This increased glutamate produces motor neurons hyperexcitability and an increment in calcium influx in cells (neurons and glia) as well as mitochondria thus, causing cell damage [63]

[DOI] [PubMed] [Google Scholar] 346.Strong S., Liew G., Michaelides M

Notably, we observed the downregulation of multiple pathways associated with inflammation, metabolism, and cellular homeostasis