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Taken together, our results suggest that alveolar macrophages are major effectors of innate immunity by modulating inflammatory responses towards a Th2 phenotype by producing IL-13, as seen in the adaptive immune response (Fig

The theory of the antitumor effects of metformin involves its action on several major signaling pathways, including indirect (insulin-dependent) and direct (activation of AMPK pathways) and corresponding targets, such as PI3K, K-RAS, mTORC, PP2A and miRNA

immune state) that are being triggered

These subunits are made up of an amino-terminal signal peptide and four central segments that are hydrophobic