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In certain conditions, the bodys demand for L-carnitine may surpass its synthesis capacity, classifying it as a conditionally essential nutrient [2]

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Nutrient interactions Endogenous biosynthesis of L-carnitine is catalyzed by the concerted action of four different enzymes (see Metabolism and Bioavailability) ( Figure 2 )

When taken empty-handed, L-carnitine is more readily absorbed and used by the body

Systematic review and meta-analysis of randomized placebo-controlled trials of folate and vitamin B12 for depression International Psychogeriatrics (2015), DOI: 10.1017/S1041610215000046 9