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In Asian and African countries, the prevalence is much higher

Arguably, the substances involved in this context choline, betaine, vitamin B6, vitamin B12 (methylcobalamin), folate (methyl-THF) and SAM all have a much more direct connection to the symptoms attributed to homocysteine and are therefore often the root cause of a disease

This can be a roadblock to some people, as daily injections are a higher bar to clear than weekly, but the troche is a low barrier to entry

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