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5 The most well-known mechanism through which GLP-1RAs affect weight loss is through the endocrine pathway, but its role in the nervous system should not be overlooked

Animal toxicology studies found no acute toxicity, organ damage, or reproductive toxicity across multiple routes and doses, but these studies lasted only up to 6 weeks

New blood vessels mean more oxygen and nutrient delivery to the damaged area

Dual agonism at the amylin receptor (a heterodimer of calcitonin receptor + RAMP1/2/3) and the calcitonin receptor in area postrema and arcuate nucleus, reducing food intake and promoting satiety