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TLRs contribute to PD by mediating the associated neuroinflammation and glial activation [69]
At day 90, 5058% of patients in the DFO group have favorable outcomes, much higher than those in the placebo group (31%), suggesting that iron chelating therapy reduces systemic iron overload and may provide long-term benefits for patients with acute stroke
62 Typical doses of zonisamide range from 200 to 600 mg daily
However, substituting the ethoxy with larger aliphatic ether groups was better tolerated both in terms of TRF1 TRFH binding and aqueous solubility ( 30 , 31 , 32 )
Siddique A, Kowdley KV
