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Furthermore, pharmacological inhibition of PHGDH by NCT-503 enhanced sensitivity to bortezomib, and reduced the intracellular redox capacity of the multiple myeloma (MM) cells [142]

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The mechanisms giving rise to the multiplicity of GST genes in Arabidopsis become apparent when their positioning on the chromosomes is analyzed (Figure 2): 34 of the GST genes are present in clusters that clearly arose from gene-duplication events

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