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The hormone GLP-1 increases feelings of fullness, curbs the desire for more food, and decreases hunger

In addition, certain criteria for the diagnosis of diabetes mellitus are shown in Table 1 [2]

The mechanism is logical: if melanocytes are still present in the follicle but functionally impaired by B12 deficiency, restoring adequate B12 can restore their function and the hairs they produce will return to their natural colour

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These effects appear to be mediated primarily through activation of phosphodiesterase 3B (138)