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Besides CVD, developing a greater understanding of cellular LCAC pathogenesis will be informative for the disease processes of rare, but often lethal, fatty acid oxidation and carnitine metabolism disorders (Merritt et al., 2018)

Upper airway obstruction : The upper airway frequently occludes entirely or partially during a central apnoea, most likely as a result of a decline in the central drive to the muscles that dilate the upper airway

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A limitation of our study was the absence of muscle biopsy, which could have provided additional data regarding intramuscular LCR levels as well as molecular and cellular responses, including proteins involved in the mTOR pathway
