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Therefore, future research should focus on establishing standardized dosing protocols through well-designed preclinical and clinical studies, considering both biological and injury-related variables to maximize the therapeutic efficacy of IGF-1 in tendon repair
They display differences in their mechanisms of action, likely mediated by their binding to different, non-overlapping epitopes of the CD38 molecule

Setria is GRAS (Generally Recognized As Safe) and has shown excellent tolerability in clinical studies

However, most of the clinical trials of anti-IGF-IR agents are conducted in unselected cancer patients

doi: 10.1046/j.1365-2265.2003.01794.x
