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However, the specific mechanism involved in this protective effect is unclear

Different cytokines (TNF- and IL-1) and PKC can trigger AP-1 through many forms of MAPKs and TKs, which in turn initiate a pathway of intracellular kinases [87]

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Alkaloids like caffeine contain electron-rich heterocyclic nitrogen and carbonyl groups that may participate in metal ion reduction, whereas polysaccharides and saponins provide multiple hydroxyl groups that serve as capping agents to prevent nanoparticle aggregation 27

In preventing hydrogen peroxide and hydroperoxide detoxification by glutathione peroxidase, homocysteine indirectly contributes to oxygenated reactive species-mediated inactivation of NO