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As you can see in the equation above its also related to the pH of the solvent

Douillard-Guilloux G, Guilloux JP, Lewis DA, Sibille E (2013)

However, as Miller says, the research linking B12 with bone health only shows an association, not a cause-effect relationship

ring A is optionally attached and is a 5-7 membered ring that is aromatic or non-aromatic and can contain one more heteroatoms (N, O, or S atoms)

doi: 10.1002/cpt196565631
