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Upon activation, the NLRP3 inflammasome promotes autocatalytic cleavage of procaspase-1 into its active form, caspase-1, which subsequently processes the pro-inflammatory cytokines pro-interleukin-1 and pro-interleukin-18 into their mature forms

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LOX enzymes, which catalyze the dioxygenation of polyenoic fatty acids to form hydroperoxides, are another source of lipid radicals

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