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Description
One of the major functions of the SHMT2 encoded enzyme is in mitochondrial thymidylate synthesis pathway via its role in glycine and tetrahydrofolate metabolism
M., Hassaballah A
However, if the purpose of the drug is to be taken up by the liver, then first-pass metabolism may be irrelevant (the drug is still metabolized into hepatic glutathione, which is what matters)
Consequently, developing biomarkers in easily accessible peripheral biofluids, such as blood, is a key priority
Rev Nutr
