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smegmatis growth inside THP-1 cells, whereas any deviation (increase or decrease) from this optimal concentration was ineffective

For example, mutations in BRCA1 and/or BRCA2 account for 510% of breast cancer and 1015% of ovarian cancer

[DOI] [PMC free article] [PubMed] [Google Scholar] 295.Ruck T, et al

As an evolutionary strategy to counteract truncation-induced toxicity resulting from impaired proteostasis, the cellular system employs compensatory responses such as phosphorylation near truncation sites
