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Mhamdi et al

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From apixaban, an anticoagulant used to treat and prevent blood clots and stroke, to bixafen, a pyrazole-carboxamide fungicide used to control diseases of rapeseed and cereal plants, the remarkable prevalence of pyrazole scaffolds in a diverse array of bioactive molecules has prompted medicinal and organic chemists to investigate novel approaches in creating pyrazole-containing compounds for various applications [174]

Because it binds poorly to IGFBPs, it remains free and biologically active in circulation far longer than native IGF-1

There are numerous factors affecting the gut barrier integrity, including infection, inflammation, a dysregulated immune response, a low-fiber dietary pattern, and stress