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Phase 1 trial, pharmacokinetics, and pharmacodynamics of dasatinib combined with crizotinib in children with recurrent or progressive high-grade and diffuse intrinsic pontine glioma

Authors Note : To push back slightly on Breckas framing peptides work because they successfully bind to specific cell receptors, not because the body recognises them as endogenous metabolites

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The slight fluctuations observed in the hydrogen bond counts across all complexes over time are likely attributed to the thermal motion

Despite the uncertainties regarding the exact conformation of Glu-451, this configuration can be considered structurally similar to the Michaelis complex and the water molecule is in a suitable position for the nucleophilic attack on the peptide group