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99,100 Preclinical evidence suggests melatonin protects ear tissues against the ototoxic (toxic to the ear) effects of certain medications

Seventy-five patients with type 1 diabetes and various forms of autonomic neuropathy were enrolled in this study: 46 patients (mean age of 38.1 12.5 years) were treated with intravenous ALA (600 mg/day) for 10 days, then with oral ALA (600 mg film tablet/day) for 50 days, while 29 patients (mean age 40.2 9.3 years) served as the untreated control group

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Such studies not only require a systematic examination of doseresponse relationships and time dynamics but must also fully consider individual differences, long-term safety, and the specificity of different types of exercise

1B) and an increase in the myotube diameters (Fig