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Binding to the EPORCD131 receptor complex, ARA-290 activates signaling cascades (e.g., JAK/STAT, PI3K/Akt) associated with cell survival, reduced apoptosis, and decreased pro-inflammatory cytokine production
MOTS-c , a peptide encoded in mitochondrial DNA and promoted as an exercise mimetic, has metabolic effects in animals but no human brain data

Gross motor skills involve moving your arms and legs
