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Extended Activity: Due to reduced binding to IGF-binding proteins, IGF-1 LR3 may produce more prolonged receptor engagement than equivalent amounts of native IGF-1 in experimental systems, allowing for detailed study of dosetime relationships and cumulative effects on cell populations

- Lapachone (ARQ761) induces DNA damage, PARP1 hyperactivation, and apoptosis in an NQO1-dependent manner (NCT02514031)

Lipid effects of peroxisome proliferator-activated receptor- agonist GW501516 in subjects with low high-density lipoprotein cholesterol: characteristics of metabolic syndrome The objective of this study was to investigate the effects of GW501516, a peroxisome proliferator-activated receptor-delta (PPAR) agonist, on lipid and lipoprotein profiles in patients with low high-density lipoprotein (HDL) cholesterol levels

The Keio University Animal Research Committee approved all animal procedures used in this study [12048-(3)]