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Key Advantages: Targets hypothalamus-pituitary-gonadal axis directly, supports natural hormone signaling, short-term use efficacy

The EGF meta-analysis is a useful reality check here, since topical growth factors are not a reliable pigment shield

Gentle enough for sensitive skin and unlikely to cause irritation at standard concentrations

Immunocytochemistry Prior to the start of experiments, glass cover slips (Bellco Glass Inc., Vineland, NJ, USA) were coated in 24-well plates (Thermo Fisher Scientific) with PLO and FN before seeding the cells

Cellular localization of somatomedin (insulin-like growth factor) messenger RNA in the human fetus