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doi: 10.18388/abp.2012_2116

A related united-atom MD model showed that the addition of cholesterol can alleviate this destruction 13,18

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Structure of the PLC Catalytic Core and Its C-Terminal Extension As in most other PLC enzymes, PLC proteins share a highly conserved catalytic core composed of an N-terminal pleckstrin homology (PH) domain, four tandem EF hand repeats, a triose phosphate isomerase (TIM)like barrel domain split into X and Y halves and which houses the active site, and a C2 domain (Figs