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The challenges in this field lie in stereochemical control and the introduction of orthogonal protecting groups

10.1016/j.pediatrneurol.2019.12.001 92

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The "coverage" charts below show how much of the daily needs can be covered by 300 grams of the food

Safety and efficacy of tapentadol ER in patients with painful diabetic peripheral neuropathy: results of a randomized-withdrawal, placebo-controlled trial
