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However, good, comprehensive double-blind trials take time and require many participants

The phase function from 2 to 170 deg

10.1371/journal.pone.0016360 PLoS One 18 DixonD

One of the most frequently discussed concerns is related to skin whitening a desired outcome for many, but also a controversial one when pursued aggressively without clinical oversight

This happens within minutes of administration in animal models
