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For example, in cancer cells, the antioxidant system is upregulated through the activation of transcription factors like NRF2, resulting in the increased production of antioxidants such as glutathione (GSH) and superoxide dismutase (SOD) to neutralize excess reactive oxygen species and prevent toxicity (60)

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In response to diminished insulin sensitivity in peripheral tissues, cells increase insulin secretion, resulting in compensatory hyperinsulinemia

Lancet 373 (9671), 12531263

Inhibition of Anti-apoptotic Mcl-1 Exerts Anti-leukemia Activity through Modulation of Leukemia-stromal Interactions and Metabolic Functions in AML