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The invasion process of curcumin triggers the expression of inflammatory cytokines or growth factors, closely associated with the pathophysiology of various diseases and lifestyles such as cardiovascular disease, obesity, diabetes, myocarditis, dementia, atherosclerotic, chronic obstructive pulmonary disease, and other conditions

doi: 10.3390/antiox10081297

Neurocrit Care

Curcumin has an excellent safety profile, with only mild gastrointestinal discomfort reported as the primary adverse effect, even at high doses (5008000 mg/day) and during long-term administration (up to 12 months)

Intravenous delivery results in immediate full-concentration exposure and typically the shortest apparent half-life because peak plasma levels degrade the fastest