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In addition, the accumulation of AGE in the tissues induces cellular oxidative stress and promotes inflammation, thus increasing the vulnerability of the target tissues [58]

After incubation, cells were gently washed two times with the 1X JC-1 dyeing buffer and 2 ml CM-blank was added into each well

Safety parameters evaluated included blood tests (measurement of AST, ALT, -glutamyl transpeptidase, hemoglobin, bilirubin levels and PT) and no patients had severe side effects, with one patient having mild diarrhea

doi: 10.1016/j.neulet.2021.136124 108

Sexual dysfunction in Peyronies disease: An analysis of 222 patients without previous local plaque therapy
