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An extremely important but unexplored avenue for treatment is preventing the involvement of non-mutant proinsulin from forming aggregates

For example, a sub-study of the Beta-Blocker Evaluation of Survival Trial (BEST) demonstrated improved survival in Arg389 homozygotes treated with bucindolol compared with those on placebo

[DOI] [PubMed] [Google Scholar] 176.Matz RL, Schott C, Stoclet JC, Andriantsitohaina R

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The antioxidants in GSE may help alleviate the oxidative stress, inflammation, and tissue damage that can occur alongside chronic diseases