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Bioengineering of probiotic yeast Saccharomyces boulardii for advanced biotherapeutics

This phenotype was absent from the catalase/peroxidase-proficient parent, showing that it depends upon H 2 O 2 stress (Figure 8C)

doi: 10.1186/s40359-018-0218-3 [DOI] [PMC free article] [PubMed] [Google Scholar] 551

Glutathione is a tripeptide made of three amino acids: cysteine, glycine and glutamic acid

These organisms have been modified through gene editing to alter their original metabolic pathways, enabling low-cost production of target active substances ( Saccharomyces cerevisiae cells while blocking the sterol branch pathway, which resulted in a significant increase in the content of the precursor mevalonate in the mutant strain (Paddon et al., 2013