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doi: 10.1016/j.yrtph.2015.06.016, [DOI] [PubMed] [Google Scholar] 222.Coles D, Frewer LJ

Trophoblastic dysfunction is a typical feature of pre-eclampsia, resulting in uterine spiral artery remodeling disorder

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The de novo synthesis pathway (e.g., serine synthesis pathway, SSP) confers metabolic autonomy by enabling endogenous serine production, particularly under nutrient-replete conditions where SSP suffices to meet proliferative demands ( Metabolic plasticity serves as a hallmark of cancer cell adaptation to microenvironmental heterogeneity