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Recordings from adults exposed to high BPA at 72 hpf identified decreased amplitudes of depolarization-elicited K + and Ca +2 currents in response to both low and high BPA exposure

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Imaging Med

Additionally, obesity and IR both contribute to -cell dysfunction and apoptosis, mechanistically explained by glucotoxicity and increased immunogenicity (the accelerator hypothesis) or by -cell exhaustion due to increased metabolic demand (the overload hypothesis) [23]