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In this review, we will provide critical analysis of our current understanding of the factors and molecular mechanisms that determine neurogenesis

GINA oversimplified: Use ICS+formoterol as the foundation for therapy starting with intermittent asthma This combination therapy delivered using the same single inhaler device was originally referred to as: SMART therapy : S ingle-inhaler for M aintenance A nd R eliever T herapy Newer acronyms include: AIR : A nti- I nflammatory R eliever MART : M aintenance A nd R eliever T herapy (daily maintenance as well as prn for relief) With severe levels of persistent asthma, step up therapy includes increasing the ICS dose, and/or adding additional medications as needed (e.g.LAMA, LTRA, OCS, or targeted biologic monoclonal antibodies)

In patients presenting with facial synkinesis, the administration of botulinum toxin injections to the buccinator muscle has been demonstrated to result in a notable improvement in the subjective assessment of disease severity

Understanding biological responses remains an important component of responsible research and experimental design