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A pivotal early event in OA cartilage pathology is the degradation of the pericellular matrix (PCM), which surrounds chondrocytes and facilitates mechanotransduction

[DOI] [PMC free article] [PubMed] [Google Scholar] 47.N-acetylcysteine reduces oxidative stress, nuclear factorB activity and cardiomyocyte apoptosis in heart failure

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Neutralization of O 2 produces H 2 O 2 , which can be metabolized into nontoxic products by a catalase and glutathione peroxidase (GPx) in conjunction with glutathione

Ongoing research into pharmacological agents or gene therapies targeting this pathway could translate into novel neuroprotective interventions in stroke management