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It has biological relevance to tissue remodeling

Provitamin A carotenoids, particularly -carotene, are the building blocks of vitamin A (retinol), produced through enzymatic and non-enzymatic processes
This shift in downregulating survival signals while upregulating apoptotic factors accelerates germ cell death and structural abnormalities in sperm

10.1016/j.intimp.2023.110924 75 RuanQ.WangC.ZhangY.SunJ

Am J Respir Cell Mol Biol 38(5):509516 Lu C, Armstrong JS (2007) Role of calcium and cyclophilin D in the regulation of mitochondrial permeabilization induced by glutathione depletion
