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While the etiology of PD is unclear, it is thought to result from an inciting traumatic event followed by aberrant fibrosis or dysregulated wound healing

A study by Peterson et al (2018) showed that while non-azotaemic cats with elevated pre-treatment SDMA were more likely to develop renal complications following stabilisation of their thyroid disease, unfortunately, having a normal pre-treatment SDMA was no guarantee of protection from renal complications

10.1371/journal.pone.0141641 5 AlehagenU.AlexanderJ.AasethJ

it was mentioned that the metabolomic analysis of patients with cardiovascular disease under the intervention of resveratrol, found Tryptophan Metabolism in relation to TMAO and cardiovascular disease (30)