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It is also anticipated that the tumor immunosuppressive milieu would be reversed by targeted intervention of important molecules involved in tumor lipid metabolism, such as CD36 and CPT1A

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AcAc is converted in a reversible reaction catalyzed by D--hydroxybutyrate dehydrogenase (BDH1), leading to the formation of BHB, or undergoes non-enzymatic decarboxylation with the formation of acetone (Figure 2) (104, 105)