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Keywords: Centella asiatica , oxidative stress, neuroinflammation, neurodegeneration, brain injury 1

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7.2 Immune balance and tolerance: regulatory roles of probiotics 7.2.1 Cytokine reprogramming: anti-inflammatory and tolerogenic pathways Acting as essential molecular messengers, cytokines play a central role in orchestrating immune and inflammatory responses and regulate a wide spectrum of additional physiological processes (243)

Why Cartilage Degenerates Several factors drive cartilage breakdown: Chronic Inflammation Inflammatory cytokines such as IL-1 and TNF- stimulate enzymes that degrade cartilage matrix

The concentration of produced ammonia was detected using an Ammonia Assay Kit (Abcam, Cambridge, UK) according to the manufacturers instructions