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This can occur due to loss of appetite, digestive issues, and muscle weakness, which are common side effects of B12 deficiency

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Concluding Remarks The development of non-cytotoxic anti-CD38 antibodies and small molecules targeting the NADase enzymatic activity of CD38 may present as an important advancement in therapies for cancers and age-related diseases, but many important questions remain about CD38 biology and potential therapeutic uses (see outstanding questions)